Werner Syndrome and Diabetes Mellitus Accompanied by Adrenal Cortex Cancer

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Werner Syndrome and Diabetes Mellitus Accompanied by Adrenal Cortex Cancer

Werner syndrome is a rare genetic disease characterized by progeria, diabetes mellitus, cataracts and various types of malignancy. However, there are few reports showing adrenal cortex cancer in subjects with Werner syndrome. We herein report an extremely rare case of Werner syndrome accompanied by adrenal cortex cancer. Based on the data obtained from blood samples, computed tomography, magnet...

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LETTER TO THE EDITOR Diabetes mellitus and cancer in Werner syndrome

Onishi et al. recently reported here an association of diabetes mellitus (DM) with neoplasm type in newly identified patients with Werner syndrome (WS), an autosomal recessive cancer predisposition syndrome with features of premature aging that include a high risk of DM (Onishi et al. in Acta Diabetol 49(Suppl 1):259–260, 2012; Epstein et al. in Medicine 45:177–121, 1966). In contrast, we did n...

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The 47,XXX karyotype is a rare sex chromosome anomaly. This karyotype is usually not associated with a characteristic physical phenotype. In the presented case, a triple-X girl patient associated with 11beta-hydroxylase deficiency is identified. The case was referred to the Endocrinology Unit at six days of age because of ambiguous genitalia. The karyotype in this case was 47,XXX, an unexpected...

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A Case of Preclinica Acromegaly Accompanied Cushing's Syndrome by Adrenal

We encountered a 58-year-old woman with acromegaly accompanied by a cortisol-secreting adrenal tumor without clinical features of hypercortisolism. The simultaneous occurrence of these two endocrinopathies in one individual is extremely rare. She was diagnosed as having diabetes mellitus 8 years ago. Afterwards, in spite of insulin therapy, her hyperglycemia could not be well controlled. Her ac...

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Reversible Cardiomyopathy Accompanied by Secondary Adrenal Insufficiency.

Case Report A 41-year-old woman was admitted to our hospital because of worsening dyspnea for 2 weeks. She experienced fatigue and shortness of breath on physical activity (5 metabolic equivalents) for 8 years after delivery, and she considered this normal. She also had meningitis 3 months before presentation that resolved in 2 weeks. There was no evidence of ischemia or infection, and she had ...

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ژورنال

عنوان ژورنال: Internal Medicine

سال: 2017

ISSN: 0918-2918,1349-7235

DOI: 10.2169/internalmedicine.56.8231